Un long voyage à travers le temps

Ta force est d’être frêle et pure infiniment ;
De traverser, le cœur en feu, tous chemins sombres,
Et d’avoir conservé, malgré la brume ou l’ombre,
Tous les rayons de l’aube en ton âme d’enfant.

Émile Verhaeren. Les Heures d’après-midi.

Articles scientifiques :

• Podshivalova K, Kerr R, Kenyon C. How a mutation that slows aging can also disproportionately extend end-of-life decrepitude. Cell Reports 2017, 19:441-50.
• Leon J, Moreno AJ, Garay BI, et coll. Peripheral elevation of a Klotho fragment enhances brain function and resilience in young, aging, and α-synuclein transgenic mice. Cell Reports 2017, 20:1360-1371.
• Bansal A, Zhu L, Yen K, et coll. Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112: E277-E286.
• Cynthia Kenyon. The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. Philosophical Transactions of the Royal Society B, 2011, 366:9-16.
• Kurosu H, Yamamoto M, Clark JD, et coll. Suppression of aging in mice by the hormone Klotho. Science 2005, 309:1829-33.
• Jenkins N , McColl G, Lithgow G. Fitness cost of extended lifespan in Caenorhabditis elegans. Philosophical Transactions of the Royal Society B 2004, 271:2523-6.
• Holzenberger M, Dupont J, Ducos B, et coll. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003, 421:182-7.
• Clancy D, Gems D, Harshman L, et coll. Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein. Science 2001, 292:104-6.
• Kuro-o M, Matsumura Y, Aizawa H, et coll. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997, 390:45-51.
• Ogg S, Paradis S, Gottlieb S, et coll. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 1997, 389:994-9.
• Kimura K, Tissenbaum H, Liu Y, et coll. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997, 277:942-6.
• Morris J, Tissenbaum H, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 1996, 382:536-9.
• Kenyon C, Chang J, Gensch, et coll. A C. elegans mutant that lives twice as long as wild type. Nature 1993, 366:461-4.
• Friedman D, Johnson T. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 1988, 118:75-86.
• Klass M. A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mechanisms of Ageing and Development 1983, 22:279-86.
• Klass M. Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mechanisms of Ageing and Development 1977, 6:413-29.
• McCay C, Cromwell M, Maynard L. The effect of retarded growth upon the length of life span and upon the ultimate body size. The Journal of Nutrition, 1935, 10:63-79.

Livres :

• Pierre de Ronsard. Discours, Derniers vers. Flammarion, 1999.
• Émile Verhaeren. Les Heures du soir. Précédées de Les Heures claires. Les Heures d’après-midi. Mercure de France, 1922. Ou Gallica-Bibliothèque nationale de France